AMD causes: the role of genetics and inflammation

The proportion of genetic factors in disease predisposition for age-related macular degeneration (AMD) is around 70% is estimated [1]. LOC387715-Gen auf dem langen Arm des Chromosoms 10 [2] . In 2005, two major genetic risk variants are identified: a change (Y402H) in the gene for the complement H (CFH) on the long arm of chromosome 1 and another in the so-called LOC387715 gene on the long arm of chromosome 10 [2 ]. As a result, further risk genetic variants found, and significantly again in innate immune system, the complement factor B (BF) and C3. Taking into account the risk variants in CFH, LOC387715 and BF is an approximately 14-fold increased 20-fold or decreased risk for AMD, the makers of all variants and risk of all protective variants in comparison to the average population [3].The involvement of the innate immune system can therefore be considered to be.The complement system consists of a complex system of plasma proteins.The exact consequences of genetic modification are still unklar.Tatsächlich was recently shown that systemic complement in AMD is detectable [4].It follows that the AMD systemic, inflammatory disease seems to be taking the macula one place with the greatest vulnerability is.Interventions for the purpose of prophylaxis or therapy seem risky, because the complement system a central component of the human immune system represents.

Literature:

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2. Scholl HP, Fleckenstein M, Charbel Issa P, Keilhauer C, Wood FG, Weber BH.An update on the genetics of age-related macular degeneration. Mol Vis.2007; 13:196-205.

3. Despriet DD, Klaver CC, van Duijn CC, Janssens AC.Predictive value of multiple genetic testing for age-related macular degeneration.Arch Ophthalmol.2007; 125 (9) :1270-1.

4. Scholl HP, Charbel Issa P, Wali M, Janzer S, Pollok-Kopp B, Börncke M, Fritsche LG, Chong NV, Fimm R, Wienke D, Wood FG, Weber BH, Oppermann M. Systemic complement activation in age-related macular degeneration.PLoS ONE.2008; 3 (7): e2593.